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Trial NCT00986687

Resource URI: http://static.linkedct.org/resource/trials/NCT00986687
linkedct:arm_group <http://static.linkedct.org/resource/arm_group/42167>
linkedct:arm_group <http://static.linkedct.org/resource/arm_group/64828>
linkedct:biospec Embryos
linkedct:biospec_retention Samples With DNA
linkedct:brief_title Oocyte Cryopreservation Comparing Fresh and Vitrified Sibling Oocytes
linkedct:collaborator_agency <http://static.linkedct.org/resource/collabagency/2479>
linkedct:condition <http://static.linkedct.org/resource/condition/6601>
linkedct:criteria Inclusion Criteria: 1. Females 21 to 37 years of age. 2. Normal serum follicle stimulating hormone (FSH) concentration <10 mIU/ml and estradiol (E2) concentration <70 pg/ml obtained on day #2 or 3 of the menstrual cycle. 3. BMI < 35. 4. No physical or gynecological abnormalities (including major uterine surgery) constituting a medical contraindication to embryo transfer and pregnancy including any known significant genetic disorders 5. Non-smoker for at least 3 months prior to study enrollment. 6. Normal antral follicle count (total  10). Exclusion Criteria: 1. Greater than 1 previous miscarriage. 2. More than 1 previous failed IVF attempt. 3. Previous poor response to ovarian stimulation (peak E2 level <1,000 pg/ml or < 4 oocytes retrieved). 4. Presence of untreated hydrosalpinx. 5. Stage III or IV endometriosis. 6. Intent to have preimplantation genetic diagnosis (PGD) of embryos 7. Unwillingness to freeze or inseminate all eligible oocytes or embryos. 8. Male partner requiring surgical sperm retrieval (MESA or TESA).
linkedct:description The necessity to cryopreserve human oocytes successfully, with the goal of achieving term pregnancies at rates equivalent to those obtained with fresh oocytes is urgent. Cryopreservation of oocytes is desirable because: 1) it would allow infertility patients to store excess oocytes instead of embryos, eliminating some of the ethical and religious concerns that accompany embryo storage; 2) permit storage of donor oocytes in egg banks, analogous to existing sperm banks. This option would allow the cryopreserved oocytes to be quarantined until screening for infectious diseases is completed, and would also avoid donor-recipient synchronization difficulties; and 3) can help cancer patients preserve their fertility before they face sterilization due to chemotherapy or radiation. Oocyte cryopreservation is therefore gaining in popularity as an option for infertility treatment as well as fertility preservation. This is a pilot study to evaluate the outcomes of oocyte vitrification using the Cryotop method in women undergoing IVF, by simultaneously evaluating embryos derived from vitrified and fresh oocytes coming from the same stimulated cycle. The primary outcome measures that will be tracked and tabulated are oocyte survival, fertilization and cleavage rate, and subsequent embryo development, compared between vitrified and fresh oocytes. Secondary outcomes are implantation, clinical pregnancy, miscarriage and live birth rates using embryos derived from the vitrified oocytes for transfer.
linkedct:download_date Information obtained from ClinicalTrials.gov on December 30, 2009
linkedct:eligibility_gender Female
linkedct:eligibility_healthy_volunteers Accepts Healthy Volunteers
linkedct:eligibility_maximum_age 37 Years
linkedct:eligibility_minimum_age 21 Years
linkedct:eligibility_sampling_method Non-Probability Sample
linkedct:eligibility_study_pop The Center for Advanced Reproductive Services patient population
linkedct:end_date June 2012
linkedct:enrollment 15 (xsd:int)
linkedct:firstreceived_date September 29, 2009
linkedct:has_dmc No
linkedct:id NCT00986687
rdfs:label Trial NCT00986687
linkedct:lastchanged_date September 29, 2009
linkedct:lead_sponsor_agency University of Connecticut Health Center
linkedct:location <http://static.linkedct.org/resource/location/327886>
linkedct:nct_id NCT00986687
linkedct:number_of_arms 0 (xsd:int)
linkedct:number_of_groups 2 (xsd:int)
linkedct:official_title Oocyte Cryopreservation: A Pilot Study Comparing Fertilization and Embryo Development Between Fresh and Vitrified Sibling Oocytes
linkedct:org_study_id 09-189-3
linkedct:overall_contact_email vscranton@nso2.uchc.edu
linkedct:overall_contact_last_name Victoria L Scranton, BS
linkedct:overall_contact_phone 860-679-4612
linkedct:overall_official <http://static.linkedct.org/resource/overall_official/10175>
linkedct:overall_status Recruiting
linkedct:oversight <http://static.linkedct.org/resource/oversight/2938>
foaf:page <http://clinicaltrials.gov/show/NCT00986687>
linkedct:phase N/A
linkedct:primary_completion_date June 2012
linkedct:primary_outcomes <http://static.linkedct.org/resource/primary_outcomes/59684>
linkedct:primary_outcomes <http://static.linkedct.org/resource/primary_outcomes/59722>
linkedct:primary_outcomes <http://static.linkedct.org/resource/primary_outcomes/61309>
linkedct:reference <http://static.linkedct.org/resource/reference/17506>
linkedct:reference <http://static.linkedct.org/resource/reference/28549>
linkedct:reference <http://static.linkedct.org/resource/reference/29710>
linkedct:reference <http://static.linkedct.org/resource/reference/32999>
linkedct:reference <http://static.linkedct.org/resource/reference/34962>
linkedct:reference <http://static.linkedct.org/resource/reference/36236>
linkedct:reference <http://static.linkedct.org/resource/reference/36611>
linkedct:reference <http://static.linkedct.org/resource/reference/36895>
linkedct:reference <http://static.linkedct.org/resource/reference/37533>
linkedct:reference <http://static.linkedct.org/resource/reference/38624>
linkedct:reference <http://static.linkedct.org/resource/reference/39979>
linkedct:reference <http://static.linkedct.org/resource/reference/45993>
linkedct:reference <http://static.linkedct.org/resource/reference/5033>
linkedct:reference <http://static.linkedct.org/resource/reference/6001>
linkedct:secondary_id 29642
linkedct:secondary_outcomes <http://static.linkedct.org/resource/secondary_outcomes/27782>
linkedct:secondary_outcomes <http://static.linkedct.org/resource/secondary_outcomes/54621>
linkedct:secondary_outcomes <http://static.linkedct.org/resource/secondary_outcomes/67113>
linkedct:source University of Connecticut Health Center
linkedct:start_date August 2009
linkedct:study_design Cohort, Prospective
linkedct:study_type Observational
linkedct:summary Vitrification is a method to cryopreserve biological specimens that are sensitive to chilling injury such as oocytes and embryos, and it has been employed with increased survival rate and live births (Hong et al., 1999; Kuleshova et al., 1999; Yoon et al., 2000; Chung et al 2000; Wu et al., 2001: Kuwayama et al 2006). In their study the researchers propose to directly compare oocyte survival, fertilizaton and embryo development between sibling oocytes. The Cryotop method of vitrification, which the researchers aim to investigate in their study, has been reported as the most efficient method for human oocytes cryopreservation (Kuwayama et al, 2005, Antinori et al, 2006, Lucena et al, 2006, Cobo et al, 2008). Follow up of over 200 infants conceived from vitrified oocytes (Chian et al, 2008) indicate that the mean birth weight and the incidence of congenital anomalies are comparable to that of spontaneous conceptions in fertile women or infertile women undergoing IVF treatment.
rdf:type linkedct:trials
linkedct:verification_date September 2009