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Trial NCT00000441

Resource URI: http://static.linkedct.org/resource/trials/NCT00000441
linkedct:brief_title Drug Therapy for Alcohol Detoxification
linkedct:condition <http://static.linkedct.org/resource/condition/744>
linkedct:criteria Inclusion Criteria: - Meets criteria for alcohol dependence and uncomplicated alcohol withdrawal syndrome. - Ability to provide informed consent, complete self-rating questionnaires, and respond to structured clinician-rated instruments. - Must live within 50 miles or one hour of the study site and have reliable transportation to the site. - Must have a significant other who will provide a collateral report, attend outpatient visits, and be available by telephone. - Subjects must be medically stable. - Must have a clinical withdrawal assessment prior to study. Exclusion Criteria: - Meets criteria for any other substance dependence syndrome other than alcohol dependence or marijuana abuse. - Use of other illicit psychoactive substances (except marijuana) in the last 7 days. - Use of pharmaceutical agents within the last 14 days that are known to lower the seizure threshold, augment or decrease the alcohol withdrawal syndrome. - History of status epilepticus or two or more seizures occurring within 24- hour period during a previous alcohol withdrawal or other forms of epilepsy. - Current major depressive illness, dementia, suicidal or homicidal ideation, or past or present schizophrenia. - Acute medical instability as characterized by hepatic encephalopathy, past or present severe liver failure. - Diabetes requiring insulin, or severe renal disease. - Pregnant females. - High blood pressure. - Individuals with vomiting who cannot take oral medications at beginning of study or whose vomiting can be controlled only with antiemetic medication. - High white blood count, or liver function test that is 3 times higher than normal. - Known hypersensitivity or previous adverse reaction to carbamazepine, lorazepam, or other benzodiazepines. - Any relevant ECG abnormality which might require hospitalization or greatly interfere with safety during outpatient withdrawal. - History of severe gastrointestinal (GI) disease which might render absorption of the medication difficult or produce medical instability of the patient during detoxification which would include active peptic ulcer disease, ulcerative colitis, regional ileitis, or evidence by history or physical examination of GI bleeding. - Familial tremor or other neurological condition, determined by history, known to produce tremor. - Unable to provide a written informed consent.
linkedct:download_date Information obtained from ClinicalTrials.gov on December 30, 2009
linkedct:eligibility_gender Both
linkedct:eligibility_healthy_volunteers No
linkedct:eligibility_maximum_age 70 Years
linkedct:eligibility_minimum_age 21 Years
linkedct:end_date December 2000
linkedct:enrollment 0 (xsd:int)
linkedct:firstreceived_date November 2, 1999
linkedct:id NCT00000441
rdfs:label Trial NCT00000441
linkedct:lastchanged_date June 23, 2005
linkedct:lead_sponsor_agency National Institute on Alcohol Abuse and Alcoholism (NIAAA)
linkedct:location <http://static.linkedct.org/resource/location/168835>
linkedct:nct_id NCT00000441
linkedct:number_of_arms 0 (xsd:int)
linkedct:number_of_groups 0 (xsd:int)
linkedct:official_title Carbamazepine and Lorazepam in Outpatient Detoxification
linkedct:org_study_id NIAAAMAL10761
linkedct:overall_status Completed
linkedct:oversight <http://static.linkedct.org/resource/oversight/2918>
foaf:page <http://clinicaltrials.gov/show/NCT00000441>
linkedct:phase Phase 4
linkedct:source National Institute on Alcohol Abuse and Alcoholism (NIAAA)
linkedct:study_design Treatment, Randomized, Double-Blind, Placebo Control, Efficacy Study
linkedct:study_type Interventional
linkedct:summary This project will provide relevant clinical information for primary care practitioners treating alcohol withdrawal syndrome in outpatient settings. This double-blind, placebo- controlled clinical trial will compare the effectiveness of lorazepam (Ativan) and carbamazepine (Tegretol) in alcoholics who meet the criteria for a diagnosis of uncomplicated alcohol withdrawal syndrome. Participants are randomized to five days of treatment with a 1-week posttreatment followup.
rdf:type linkedct:trials
linkedct:verification_date August 2002