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Trial NCT00000422

Resource URI: http://static.linkedct.org/resource/trials/NCT00000422
linkedct:brief_title Tailored Treatments of Fibromyalgia
linkedct:condition <http://static.linkedct.org/resource/condition/4899>
linkedct:criteria Inclusion Criteria: - Female - Able to visit Seattle based clinic 9 times - Meet ACR criteria for FMS Exclusion Criteria: - Pregnancy - Exercise contraindicated by physician due to other medical conditions - Significant psychopathology - Do not meet FMS criteria - Cardiac problems
linkedct:description Fibromyalgia syndrome (FMS) is a prevalent, chronic musculoskeletal pain disorder. Despite extensive study, researchers do not understand well the etiology and pathophysiologic mechanisms of FMS, and have not shown any treatment to be universally effective. We propose that FMS is a complex disorder involving multiple factors, both physical and psychosocial-behavioral. In our previous research, we demonstrated that FMS patients are heterogeneous in the psychosocial-behavioral axis and can be classified into three distinct subgroups on the basis of their psychosocial adaptation to symptoms. In this study we will extend our previous research and attempt to match treatments to patients' psychosocial-behavioral characteristics. Specifically, we will test the efficacy of uniquely tailored treatment for each psychosocial subgroup. We will treat three groups of FMS patients with one of three treatment protocols involving standard physical therapy and varying psychological treatments. A total of 312 FMS patients will undergo six half-day interdisciplinary treatment sessions consisting of psychological treatments and physical therapy emphasizing aerobic conditioning, pacing, and body mechanics. All protocols include a standardized physical therapy and either cognitive-behavioral pain management therapy, interpersonal skill training, or supportive counseling. In addition to the treatment outcome study, we will prospectively assess various symptoms of FMS in the patients' natural habitats to better understand covariations of FMS symptoms. Patients will do repeated daily monitoring using a palm-top computer (ecological momentary assessment), which will permit us to evaluate process ratings compared to retrospective reports. Overall, the results of these studies should establish the benefit of matching treatments to patient characteristics and enhance our understanding of the roles of cognitive-affective-behavioral adaptation by people with FMS.
linkedct:download_date Information obtained from ClinicalTrials.gov on December 30, 2009
linkedct:eligibility_gender Female
linkedct:eligibility_healthy_volunteers No
linkedct:eligibility_maximum_age 65 Years
linkedct:eligibility_minimum_age 21 Years
linkedct:end_date May 2004
linkedct:enrollment 312 (xsd:int)
linkedct:firstreceived_date November 3, 1999
linkedct:id NCT00000422
rdfs:label Trial NCT00000422
linkedct:lastchanged_date March 28, 2008
linkedct:lead_sponsor_agency National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
linkedct:location <http://static.linkedct.org/resource/location/220436>
linkedct:nct_id NCT00000422
linkedct:number_of_arms 0 (xsd:int)
linkedct:number_of_groups 0 (xsd:int)
linkedct:official_title Subgroups of FMS: Symptoms, Beliefs and Tailored Treatments
linkedct:org_study_id R01 AR44724
linkedct:overall_official <http://static.linkedct.org/resource/overall_official/13570>
linkedct:overall_status Completed
linkedct:oversight <http://static.linkedct.org/resource/oversight/2918>
foaf:page <http://clinicaltrials.gov/show/NCT00000422>
linkedct:phase Phase 2/Phase 3
linkedct:primary_completion_date May 2004
linkedct:results_reference <http://static.linkedct.org/resource/results_reference/1537>
linkedct:results_reference <http://static.linkedct.org/resource/results_reference/1538>
linkedct:results_reference <http://static.linkedct.org/resource/results_reference/1847>
linkedct:results_reference <http://static.linkedct.org/resource/results_reference/268>
linkedct:results_reference <http://static.linkedct.org/resource/results_reference/4263>
linkedct:results_reference <http://static.linkedct.org/resource/results_reference/4804>
linkedct:secondary_id NIAMS-036
linkedct:source National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
linkedct:start_date July 1998
linkedct:study_design Treatment, Randomized, Single Blind, Active Control, Single Group Assignment, Efficacy Study
linkedct:study_type Interventional
linkedct:summary This study will evaluate the effects of matching treatments to people with fibromyalgia syndrome (FMS) on the basis of their psychosocial and behavioral characteristics. We will look at how patients respond to a rehabilitation program that includes physical therapy and information about fibromyalgia. We will combine this program with psychological treatments that are either matched or mismatched to the way patients cope with and adapt to symptoms of FMS. The second aim of our study is to better understand how different FMS symptoms may vary together and how these symptoms change as a result of treatment in a person's natural environment. People with FMS and healthy people of the same ages will record their moods, thoughts, symptoms, activities, and fatigue levels three times a day for 2 weeks. Participants will use palm-top computers to record these "real-time" assessments. This approach will permit people to rate how they feel at a particular time rather than looking back in time.
rdf:type linkedct:trials
linkedct:verification_date March 2008