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Trial NCT00000406

Resource URI: http://static.linkedct.org/resource/trials/NCT00000406
PropertyValue
linkedct:brief_title Effects of Strength Training on Knee Osteoarthritis
linkedct:condition <http://static.linkedct.org/resource/condition/9366>
linkedct:criteria Inclusion Criteria: - Males and females 60 to 100 years of age Exclusion Criteria: - Knee joint replacement surgery - Diabetes mellitus - Uncontrollable hypertension - Neuropathies of the lower extremity - Poor mental cognition (i.e., inability to follow instructions)
linkedct:description Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strengthening exercise, we will perform a randomized clinical trial of lower extremity strength training using four subgroups of people: (1) OA with knee pain; (2) OA without knee pain; (3) no OA with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will determine whether people assigned to strength training have lower pain scores and/or slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises (i.e., range-of-motion exercises). We are including the fourth group to determine whether those with OA (groups 1 & 2) exhibit the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain. We will also prospectively monitor changes in body composition and bone mass, quality of life, and symptoms of depression.
linkedct:download_date Information obtained from ClinicalTrials.gov on December 30, 2009
linkedct:eligibility_gender Both
linkedct:eligibility_healthy_volunteers Accepts Healthy Volunteers
linkedct:eligibility_maximum_age N/A
linkedct:eligibility_minimum_age 60 Years
linkedct:end_date November 2006
linkedct:enrollment 280 (xsd:int)
linkedct:firstreceived_date November 3, 1999
linkedct:id NCT00000406
rdfs:label Trial NCT00000406
linkedct:lastchanged_date December 20, 2007
linkedct:lead_sponsor_agency National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
linkedct:location <http://static.linkedct.org/resource/location/184838>
linkedct:nct_id NCT00000406
linkedct:number_of_arms 0 (xsd:int)
linkedct:number_of_groups 0 (xsd:int)
linkedct:official_title Effects of Strength Training on Knee Osteoarthritis (OA)
linkedct:org_study_id P60 AR20582 Substudy EEHSR3
linkedct:overall_official <http://static.linkedct.org/resource/overall_official/925>
linkedct:overall_status Completed
linkedct:oversight <http://static.linkedct.org/resource/oversight/2918>
foaf:page <http://clinicaltrials.gov/show/NCT00000406>
linkedct:phase Phase 2
linkedct:primary_completion_date November 2006
linkedct:results_reference <http://static.linkedct.org/resource/results_reference/6499>
linkedct:secondary_id NIAMS-022
linkedct:source National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
linkedct:start_date September 1977
linkedct:study_design Treatment, Randomized, Single Blind, Active Control, Single Group Assignment, Efficacy Study
linkedct:study_type Interventional
linkedct:summary To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will look at whether people who do strength training have less pain and/or slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening, range-of-motion exercises. We are including the fourth group to find out whether people with OA (groups 1 & 2) have the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain.
rdf:type linkedct:trials
linkedct:verification_date December 2007