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Trial NCT00000243

Resource URI: http://static.linkedct.org/resource/trials/NCT00000243
linkedct:brief_title Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone
linkedct:condition <http://static.linkedct.org/resource/condition/9249>
linkedct:criteria Inclusion Criteria: - Meets criteria for opioid dependence Exclusion Criteria: - Significant medical or psychiatric illness
linkedct:description Buprenorphine is a mixed agonist-antagonist opioid that is being developed as a treatment for opioid dependence. Because buprenorphine is a partial mu agonist opioid, under certain conditions it is possible for buprenorphine to precipitate opioid withdrawal in opioid dependent individuals. A person with a high level of physical dependence could experience buprenorphine-related precipitated withdrawal. The purpose of this study is to test the acute effects of different doses of buprenorphine/naloxone in opioid dependent individuals maintained on methadone. The study is designed to provide dosing schedules similar to those that might be initially used in a physician's office.
linkedct:download_date Information obtained from ClinicalTrials.gov on December 30, 2009
linkedct:eligibility_gender Both
linkedct:eligibility_healthy_volunteers Accepts Healthy Volunteers
linkedct:eligibility_maximum_age 55 Years
linkedct:eligibility_minimum_age 18 Years
linkedct:end_date January 2004
linkedct:enrollment 16 (xsd:int)
linkedct:firstreceived_date September 20, 1999
linkedct:id NCT00000243
rdfs:label Trial NCT00000243
linkedct:lastchanged_date March 15, 2007
linkedct:lead_sponsor_agency National Institute on Drug Abuse (NIDA)
linkedct:location <http://static.linkedct.org/resource/location/163316>
linkedct:nct_id NCT00000243
linkedct:number_of_arms 0 (xsd:int)
linkedct:number_of_groups 0 (xsd:int)
linkedct:official_title Transitioning Patients From Methadone to Buprenorphine/Naloxone for Treating Opioid Dependence
linkedct:org_study_id NIDA-08045-1
linkedct:overall_official <http://static.linkedct.org/resource/overall_official/16648>
linkedct:overall_status Terminated
linkedct:oversight <http://static.linkedct.org/resource/oversight/2920>
foaf:page <http://clinicaltrials.gov/show/NCT00000243>
linkedct:phase N/A
linkedct:primary_outcomes <http://static.linkedct.org/resource/primary_outcomes/16254>
linkedct:primary_outcomes <http://static.linkedct.org/resource/primary_outcomes/1803>
linkedct:secondary_id DPMC
linkedct:secondary_id R01-08045-1
linkedct:source National Institute on Drug Abuse (NIDA)
linkedct:start_date September 2002
linkedct:study_design Treatment, Randomized, Double-Blind, Dose Comparison, Parallel Assignment, Pharmacodynamics Study
linkedct:study_type Interventional
linkedct:summary Buprenorphine is a drug that may be helpful in treating opioid dependent individuals who were previously maintained on methadone. The purpose of this study is to determine the effects of different doses of buprenorphine/naloxone in treating opioid dependent individuals who were previously maintained on methadone.
rdf:type linkedct:trials
linkedct:verification_date March 2007