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Trial NCT00000169

Resource URI: http://static.linkedct.org/resource/trials/NCT00000169
PropertyValue
linkedct:brief_title The Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study
linkedct:condition <http://static.linkedct.org/resource/condition/8512>
linkedct:criteria Children were eligible if they were enrolled in the first through eighth grades in selected schools in Eutaw, Alabama; Houston, Texas; Orinda, California; or Irvine, California in the 1997-98 academic year and in the first grade only in Eutaw, Houston, and Irvine in the 1998-99 academic year.
linkedct:description The Orinda Longitudinal Study of Myopia (OLSM) was started in 1989 to investigate normal eye growth and the development of myopia in over 1,200 school-aged children to date. Beginning in 1997, three parallel study phases are being conducted. Phase 1 investigates additional factors that may predict the onset of juvenile myopia (accommodative function, peripheral refractive error, intraocular pressure, and school achievement). Phase 2 compares and contrasts the optical ocular components and refractive error profiles of other ethnic groups with the predominantly Caucasian Orinda database. Phase 3 conducts DNA-based studies on the prevalent OLSM myopes and their families to use these phenotypically well-characterized children and a panel of candidate genes to look for evidence of genetic factors. In parallel with the candidate gene association, family material is used in an allele sharing approach to identify loci using highly variable, PCR-based markers. In Phase 1 we continue to examine Orinda Union School District children in grades 1 through 8 (ages 6 through 14 years) annually. The measurement of accommodative response, accommodative lag, phoria, response AC/A ratio, peripheral refractive error, and intraocular pressure will be added to the existing protocol, and photokeratoscopy and two measures of tonic accommodation will be eliminated to minimize respondent burden. Parents of children in the study will be contacted for their permission to release school achievement data (Iowa Test of Basic Skills). Phase 2 adds a major component by adding three clinical centers to assess the influence of ethnicity on normal ocular and refractive error development. Children in these three are examined annually with initial enrollment in all grades from 1 through 8 using the revised OLSM protocol as described above. Increased prevalence of myopia among children of myopic parents, twin studies, segregation analysis, and our own preliminary analyses from the OLSM support a genetic etiologic component for myopia. In phase 3, we use the phenotypic characterization of children in the Orinda Longitudinal Study of Myopia to identify prevalent cases of myopia and their families. These well-defined phenotypic myopes and non-myopic siblings and their parents are being explored, seeking to develop a panel of candidate genes for myopia and to conduct an allele sharing analysis in these families The Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study is a multi-center, observational investigation of ocular development and refractive error development in schoolchildren. It adds three clinical centers to the Orinda Longitudinal Study of Myopia (OLSM), begun in 1989, specifically to describe normal ocular growth in children ages 6 to 14 years, and to develop the ability to predict juvenile onset myopia before it is clinically evident. In addition to the more than 1,300 predominantly Caucasian children enrolled in the OLSM, three additional clinical sites enroll African-American, Hispanic, and Asian children. The children are examined annually for at least four years. Examinations include visual acuity, refraction by a variety of methods (cycloplegic autorefraction being the primary outcome measure), cover test at distance and near, accommodative response assessment with the autorefractor, response AC/A ratio measurement, videophakometry, peripheral refraction, and A-scan ultrasonography. Patients are examined at 4 clinical centers. The clinical centers have enrolled 3,493 patients as of April 28, 1999.
linkedct:download_date Information obtained from ClinicalTrials.gov on December 30, 2009
linkedct:eligibility_gender Both
linkedct:eligibility_healthy_volunteers Accepts Healthy Volunteers
linkedct:eligibility_maximum_age 14 Years
linkedct:eligibility_minimum_age 6 Years
linkedct:enrollment 0 (xsd:int)
linkedct:firstreceived_date September 23, 1999
linkedct:id NCT00000169
rdfs:label Trial NCT00000169
linkedct:lastchanged_date June 23, 2005
linkedct:lead_sponsor_agency National Eye Institute (NEI)
linkedct:location <http://static.linkedct.org/resource/location/178017>
linkedct:location <http://static.linkedct.org/resource/location/202703>
linkedct:location <http://static.linkedct.org/resource/location/214972>
linkedct:nct_id NCT00000169
linkedct:number_of_arms 0 (xsd:int)
linkedct:number_of_groups 0 (xsd:int)
linkedct:org_study_id NEI-72
linkedct:overall_contact_email jones.809@osu.edu
linkedct:overall_contact_last_name Lisa A. Jones, Ph.D.
linkedct:overall_contact_phone 1-614-292-7097
linkedct:overall_status Recruiting
linkedct:oversight <http://static.linkedct.org/resource/oversight/2918>
foaf:page <http://clinicaltrials.gov/show/NCT00000169>
linkedct:phase N/A
linkedct:reference <http://static.linkedct.org/resource/reference/24890>
linkedct:reference <http://static.linkedct.org/resource/reference/27974>
linkedct:reference <http://static.linkedct.org/resource/reference/3954>
linkedct:reference <http://static.linkedct.org/resource/reference/4424>
linkedct:reference <http://static.linkedct.org/resource/reference/4506>
linkedct:reference <http://static.linkedct.org/resource/reference/45340>
linkedct:reference <http://static.linkedct.org/resource/reference/45497>
linkedct:reference <http://static.linkedct.org/resource/reference/45648>
linkedct:reference <http://static.linkedct.org/resource/reference/47727>
linkedct:reference <http://static.linkedct.org/resource/reference/48013>
linkedct:reference <http://static.linkedct.org/resource/reference/50579>
linkedct:reference <http://static.linkedct.org/resource/reference/50841>
linkedct:reference <http://static.linkedct.org/resource/reference/5099>
linkedct:reference <http://static.linkedct.org/resource/reference/51303>
linkedct:reference <http://static.linkedct.org/resource/reference/53607>
linkedct:source National Eye Institute (NEI)
linkedct:start_date April 1999
linkedct:study_design Natural History, Longitudinal
linkedct:study_type Observational
linkedct:summary To compare and contrast normal eye growth, ocular component development, and refractive error development in Hispanic, African-American, and Asian schoolchildren with what happens in Caucasian children from the Orinda Longitudinal Study of Myopia. To investigate risk factors for the development of myopia. To conduct DNA-based studies on nearsighted children and their families.
rdf:type linkedct:trials
linkedct:verification_date June 2001